Both layouts drop the number pad. The difference is one row of keys and about three centimetres of desk.

65% 75%
Keys 68 84
Function row On a layer Its own row
Arrow keys Yes Yes
Suits Small desks, big mouse swipes Work that leans on F keys

Pick 65% if

You want the most room for your mouse and rarely touch the F keys. Volume, brightness and F5 still exist; they sit on a layer you reach with Fn.

Pick 75% if

You use shortcuts built on the function row, or you just do not want to think about layers. You give up very little desk for it.